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KMID : 0881720110260010043
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Journal of Food Hygiene and Safety
2011 Volume.26 No. 1 p.43 ~ p.48
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In vivo Acute Toxicity of Silicon Dioxide Nanoparticle to Mice after Intraperitonial Injection
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Cha Chun-Nam
Jung Won-Chul
Lee Yeo-Eun
Yoo Chang-Yeul
Kim Gon-Sup
Kim Eui-Kyung
Kim Suk
Lee Hu-Jang
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Abstract
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For the application of nano-sized material in various fields, the evaluation of nano-sized material toxicity is important. In the present study, various concentrations of 200 nm-sized silicon dioxide nanoparticle suspension were intraperitonially injected into mice to identify the toxicity of silicon dioxide nanoparticle in vivo. In the hematological analysis of group II treated with silicon dioxide nanoparticle 100 mg/kg body weight, lymphocytes and monocytes were significantly different compared to the control group. In group III treated with silicon dioxide nanoparticle 200 mg/kg body weight, lymphocytes, monocytes and hemoglobin were significantly different compared to the control group. In blood biochemical analysis of group III, the concentration of AST, ALT, BUN, and creatinine were significantly different compared to the control group. Histopathologic examination of the kidney indicated a mild injury only in mice received 200 mg/kg silicon dioxide nanoparticle. According to the results of the present study, the significant differences in the hematological and blood biochemical analyses and abnormal histopathological findings in the mouse kidney may have been related to exposure to silicon dioxide nanoparticle.
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KEYWORD
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Silicon Dioxide nanopaticle, Acute toxicity, ICR mouse
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